NS-032 is a potent inhibitor of cyclin-dependent kinases

SNS-032(BMS-387032) is a potent inhibitor of cyclin-dependent kinases (cdks) 9, 2 and 7 (IC50 values are 4, 38 and 62 nM respectively).

Abbreviations: AUC_INF, area under the concentration versus time curve from time zero to infinity; CL, total body clearance; C_max, maximum plasma concentration; T_1/2, terminal half-life; MRT_INF, mean residency time when the drug concentration-time profile is extrapolated to infinity; V_ss, apparent volume of distribution at steady-state; CV%, percent coefficient of variation. * n = 6.