Biotinylated Mouse CD5 Protein, His Tag

Description :
FAQ COA 已发表文献 CD5, also known as Leu-1, Ly-1, and T1, is a 67 kDa transmembrane glycoprotein in the scavenger receptor superfamily. CD5 has been shown to interact homophilically, with CD72 on B cells, and with beta-glucan components of fungal cell walls. CD5 expression on developing thymocytes is positively regulated by signaling through the T cell antigen receptor (TCR) and is up_x005f_x001e_regulated on tolerized peripheral CD4+ cells. It inhibits TCR signaling and promotes T cell nonresponsiveness and survival. CD5 signaling inhibits the generation of regulatory T cells but promotes the development of Th17 cells. Within the B cell lineage, CD5 is expressed on B-1a cells, anergic B cells, and IL-10 producing regulatory B cells. CD5 is also involved in the cellular entry of hepatitis C virus into T cells. 产品性质 Synonyms CD5 molecule; CD5; LEU1; T1; CD5 antigen Uniprot No. P13379 Source Recombinant Biotinylated Mouse CD5 Protein is expressed from HEK293 Cells with His tag at the C-terminal. It contains Ser25-Pro371. Molecular Weight The protein has a predicted MW of 38.9 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Tris-Bis PAGE result. Physical Appearance Liquid Solution Purity > 95% as determined by SDS-PAGE and HPLC Endotoxin 1.0EU per 1g of the protein by the LAL method. Formulation Supplied as 0.22m filtered solution in PBS (pH 7.4).