Biotinylated Human NKG2D/CD314 Protein, His-Avi Tag

Description :
FAQ COA 已发表文献 NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. Human NKG2D is expressed on CD8+alpha beta T cells, gamma T cells, NK cells and NKT cells. In mouse systems NKG2D also occurs on macrophages. Human ligands for NKG2D include MICA, MICB, and ULBP1, 2, and 3. Expression of NKG2D ligands occurs in epithelial cells, tumor cells and under conditions of stress or infection. NKG2D exists as a disulfide-linked homodimer that delivers an activating signal upon ligand binding. NKG2D has been implicated in anti-tumor surveillance and the immune response against viral infection. 产品性质 Synonyms CD314; D12S2489E; KLR; NKG2-D; NKG2D Uniprot No. P26718 Source Recombinant Biotinylated Human NKG2D/CD314 Protein is expressed from HEK293 Cells with His tag and Avi tag at the N-terminal. It contains Phe78-Val216. Molecular Weight The protein has a predicted MW of 19.0 kDa. Due to glycosylation, the protein migrates to 36-40 kDa based on Tris-Bis PAGE result. Physical Appearance Sterile Filtered White lyophilized (freeze-dried) powder. Purity > 95% as determined by SDS-PAGE and HPLC Endotoxin 1.0EU per 1g of the protein by the LAL method. Formulation Lyophilized from 0.22m filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization. Reconstitution Centrifuge tubes before opening. Reconstituting to a concentration more than 100g/mLis recommended. Dissolve the lyophilized protein in distilled water.