Recombinant Human IGF2R Protein, His-Avi Tag

Description :
FAQ COA 已发表文献 IGF-II R is a type I transmembrane glycoprotein that contains a 2,264 aa extracellular region, a 23 aa transmembrane segment segment and a164aa cytoplasmic tail.The extracellular region consists of 15 contiguous “binding” repeats of about 150 aa each.This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. 产品性质 Synonyms CI-MPR; M6PR; IGF-II receptor; CD222; MPRI; IGF-IIR Uniprot No. P11717 Source Recombinant Human IGF2R Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal. It contains Glu47-Met1508. Molecular Weight The protein has a predicted MW of 164.90 kDa. Due to glycosylation, the protein migrates to 165-200 kDa based on Tris-Bis PAGE result. Purity > 95% as determined by SDS-PAGE and HPLC Endotoxin 1.0EU per 1g of the protein by the LAL method. Formulation Lyophilized from 0.22m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. Reconstitution Centrifuge tubes before opening. Reconstituting to a concentration more than 100 g/mL`is recommended (usually we use 1mg/mLsolution for lyophilization). Dissolve the lyophilized protein in distilled water.