Recombinant Human LILRB5/CD85c/LIR-8(His-Avi Tag)

Description :
FAQ COA 已发表文献 LIR8, also known as CD85c and LILRB5, belongs to the Leukocyte immunoglobulin-like receptors (LILR) family of transmembrane glycoproteins involved in regulating immune responses. There are at least thirteen LILR family members and are divided into activating (LILRA) or inhibiting (LILRB) molecules. Mature human LIR8 consists of an extracellular domain (ECD) with four Ig-like domains, a transmembrane segment, and a cytoplasmic domain with two immunoreceptor tyrosine-based inhibitory motifs (ITIM). Alternative splicing of human LIR8 generates at least 2 isoforms, one lacking the second Ig-like domain. The LILR family appears to be primate-specific receptors in terms of sequence homology. LIR8 is expressed on NK cells and in the tryptic granules of mast cells and negatively regulates immune cell activation. It is present on the mast cell surface following cell activation and degranulation. Activated mast cells may also release soluble forms of LIR8. 产品性质 别名 CD85C ; LIR-8; LIR8 Uniprot No. O75023.1 Recombinant Human LILRB5/CD85c/LIR-8Protein is expressed from HEK293Cells with His tag and Avi tag at the C-terminal. It contains Arg18-His456. 分子量 Approximately 49.9 kDa. Due to glycosylation, the protein migrates to 67-72 kDa based on Tris-Bis PAGE result. > 95% as determined by SDS-PAGE. 内毒素 1.0EU per 1g of the protein by the LAL method. Lyophilized from 0.22m filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization. 复溶 Centrifuge tubes before opening. Reconstituting to a concentration more than 100 g/mL is recommended (usually we use 1mg/mLsolution for lyophilization). Dissolve the lyophilized protein in distilled water.