Recombinant Human MMP-14/MT1-MMP Protein

Description :
FAQ COA 已发表文献 As the first member of membrane type (MT) MMPs, MMP-14, also known as MT1-MMP, plays an important role in extracellular matrix (ECM) remodeling by being able to degrade type I collagen, activate pro-MMP-2 and process cell adhesion molecules such as CD44 and integrin alphaV. MMP-14 is therefore a key enzyme in many physiological and pathological processes such as angiogenesis and tumor invasion. Structurally, MMP-14 consists of the following domains: a pro domain containing the furin cleavage site, a catalytic domain containing the zinc-binding site, a hinge region, a hemopexin-like domain, a transmembrane domain, and a cytoplamasic tail. Product Properties Synonyms MMP-X1, MT-MMP 1, MT1-MMP Accession P50281 GeneID 4323 Source E.coli-derived human MMP-14 protein, Ala21-Gly284. Molecular Weight Approximately 29.6 kDa. AA Sequence ALASLGSAQS SSFSPEAWLQ QYGYLPPGDL RTHTQRSPQS LSAAIAAMQK FYGLQVTGKA DADTMKAMRR PRCGVPDKFG AEIKANVRRK RYAIQGLKWQ HNEITFCIQN YTPKVGEYAT YEAIRKAFRV WESATPLRFR EVPYAYIREG HEKQADIMIF FAEGFHGDST PFDGEGGFLA HAYFPGPNIG GDTHFDSAEP WTVRNEDLNG NDIFLVAVHE LGHALGLEHS SDPSAIMAPF YQWMDTENFV LPDDDRRGIQ QLYG Tag None Physical Appearance Sterile colorless liquid. Purity >95% by SDS-PAGE and HPLC analyses. Biological Activity Test in Process. Endotoxin Formulation Lyophilized from a 0.2 m filtered concentrated solution in 20 mM Tris-HCl, pH 7.4, 300 mM NaCl, 3 mM CaCl2, 10 M ZnCl2, with 30% glycerol.