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Drugs R D (2014) 14:177?84 DOI 10.1007/s40268-014-0055-ORIGINAL Investigation ARTICLESwitching a-Glucosidase Inhibitors to Miglitol Reduced Glucose Fluctuations and Circulating Cardiovascular Disease Risk Elements in Sort two Diabetic Japanese PatientsNatsuyo Hariya ?Kazuki Mochizuki ?Seiya Inoue ?Miyoko Saito ?Masahiro RORγ Inhibitor Storage & Stability Fuchigami Toshinao Goda ?Takeshi Osonoi?Published online: 31 July 2014 ?The Author(s) 2014. This article is published with open access at SpringerlinkAbstract Background and Objectives In this study we examined the effects of switching a-glucosidase inhibitors (a-GI) from acarbose or voglibose to miglitol on glucose fluctuations and circulating concentrations of cardiovascular illness danger factors, like soluble adhesion molecules (sE-selectin, sICAM-1 and sVCAM-1), a chemokine monocyte chemoattractant protein (MCP)-1, plasminogen activator inhibitor-1, and fatty acid-binding protein four, in form 2 diabetic individuals for 3 months. Solutions We enrolled 47 Japanese sufferers with variety two diabetes, with HbA1c levels with 7.26 ?0.five (imply ?common deviation), and who have been treated with the highest authorized dose of acarbose (one hundred mg/meal) or voglibose (0.three mg/meal) in mixture with insulin or sulfonylurea.N. Hariya Division of Engineering, Interdisciplinary Graduate College of Medicine and Engineering, University of Yamanashi, Kofu, Japan K. Mochizuki ?S. Inoue ?T. Goda Division of Food and Nutrition.