iversity, Seoul; Division of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong; 3 Division of Oral and Maxillofacial Surgery, College of Dentistry, Dental Investigation Institute, Seoul National University, Seoul; 4 Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyungpook National University, Daegu; five Division of Endocrinology and Metabolism, Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung; 6 Division of Endocrinology and Metabolism, Department of Internal Medicine, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon; 7 Department of Oral and Maxillofacial Surgery, School of Dentistry, Kyung Hee University, Seoul; 8 Division of Oral and Maxillofacial Surgery, Institute of Oral Overall health Science, Ajou University Dental Hospital, Ajou University School of Medicine, Suwon; 9 Department of Orthopaedic Surgery, Seoul National University CCR4 Antagonist web Bundang Hospital, Seoul National University College of Medicine, Seongnam; ten Department of Nuclear Medicine, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea1Corresponding authorsYong-Dae Kwon Department of Oral and Maxillofacial Surgery, College of Dentistry, Kyung Hee University, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea Tel: +82-2-958-9440, Fax: +82-2-966-4572 E-mail: yongdae.kwon@gmail; [email protected] Deog-Yoon Kim Department of Nuclear Medicine, Kyung Hee University Hospital, Kyung Hee University College of Medicine, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea Tel: +82-2-958-8211, Fax: +82-2-968-1848 E-mail: [email protected]: October 22, 2021 Revised: November 9, 2021 Accepted: November 15, 2021 Jin-Woo Kim and Mi Kyung Kwak contributed equally to this work and ought to be considered co-first authors. Yong-Dae Kwon and Deog-Yoon Kim contributed equally to this perform and ought to be regarded co-corresponding authors. Copyright 2021 The Korean Society for Bone and Mineral Study This can be an Open Access report distributed below the terms with the Creative Commons ATR Inhibitor supplier Attribution Non-Commercial License (creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, supplied the original perform is effectively cited.Antiresorptives will be the most widely prescribed drugs for the treatment of osteoporosis. They may be also applied in malignant bone metastases, several myeloma, and Paget’s disease, and present therapeutic efficacy on these ailments. Nonetheless, it was reported that the occurrence of osteonecrosis from the jaw (ONJ) might be related to antiresorptive exposures, and there happen to be many cases concerning this situation. Consequently, a clearer definition and treatment recommendations were required for this disease. The American Society for Bone and Mineral Analysis and also the Amnerican Association of Oral and Maxillofacial Surgeons reported statements on bisphosphonate-related ONJ (BRONJ), and also a revised version was not too long ago presented. Within the revised edition, the diagnosis BRONJ was changed to medication-related ONJ (MRONJ), which reflects consideration from the reality that ONJ also occurs for denosumab, a bone resorption inhibitor from the receptor activator on the nuclear factor-B ligand antibody loved ones, and bevacizumab, an anti-angiogenesis inhibitor. The Korean Society for Bone and Mineral Study and also the Korean Association
