A, Bolivia, Chile, Ecuador, Mexico, Peru, and the USA. It reduces crop yield in tomatoes (Solanum lycopersicum L.), potatoes (Solanum tuberosum), beans (Phaseolus vulgaris L.), and sugar beets (Beta vulgaris). The nematode ranks among the “top ten” plant-parasitic nematodes of phytosanitary significance [1]. It is estimated it meets the criteria to be a potential danger inside the EU [2]. Management strategies of plant-parasitic nematodes are cultural practices (crop rotation), mixed-cropping, organic amendments, resistant crop cultivars, biological handle [3],Molecules 2021, 26, 2216. https://doi.org/10.3390/moleculeshttps://www.mdpi.com/journal/moleculeses 2021, 26, x FOR PEER REVIEWMolecules 2021, 26, strategies2 ofof plant-parasitic nematodes are cultural practices (crop rotation), mixed-crop2 of 13 ping, organic amendments, resistant crop cultivars, biological handle [3], chemical nematicides, and bioactive merchandise of plant origin. Among these strategies, all-natural product usage represents a vitalnematicides, and bioactive goods of plant origin. due to chemical choice for controlling phytopathogenic nematodes Amongst these tactics, their low effect on the environmentrepresents a vitalorganisms. controlling phytopathogenic nematodes all-natural item usage and non-target option for Within the search for botanic nematicides, a few of the most recent IL-8 Antagonist Purity & Documentation proposals are employing Steviaand non-target organisms. Inside the search due to their low impact on the environment rebaudiana and Origanum for botanic nematicides, some of the showed this effect [7,8]. Inside the Stevia vulgare to handle Meloidogyne; in vivo experiments most current proposals are usingcase of rebaudiana and Origanum vulgare from T. lunulate [9], Cosmos sulphureus [6], Senecio salignus N. aberrans, crude herbal extractsto manage Meloidogyne; in vivo experiments showed this effect [7,8]. In [6], Witheringiathe case of N.[6], and Lantana c ara [6] showed in vitro nematicidal activ- sulphureus [6], stramoniifolia aberrans, crude herbal extracts from T. lunulate [9], Cosmos Senecio salignus [6], Witheringia stramoniifolia [6], and Lantana c ara [6] showed in vitro ity at 500 mL-1 (70 ) to second-stage juvenile (J2) folks. Simultaneously, in vivo nematicidal activity at 500 mL-1 Mill and second-stage juvenile (J2) protection from infection of Lycopersicum esculentum (70 ) to Capsicum annumm plants individuals. Simultaneously, in vivo protection from infection of Lycopersicum esculentum Mill and occurred with extracts of Tagetes BACE1 Inhibitor Formulation erecta [9] and Trichilia galuca [10], respectively. There are Capsicum annumm plants with toxic potential for the handle of N. and Trichilia galuca [10], only two reports of all-natural compounds occurred with extracts of Tagetes erecta [9] aberrans: respectively. There are aberrans reports of all-natural compounds with toxic potential for the capsidiol acts as a nematostatic on N. only twoJ2 (90 immobility) at 1.5 mL-1 after 72 manage of N. aberrans: capsidiol acts as a nematostatic on N. mL-1 J2 (90 h [11]; and numerous cadinenes affect immobility-mortality (LC50 25.411.4 aberrans ) and immobility) -1 at 1.five (IC50 31.236.71 h mL ) [12]. Identification of affect immobility-mortality (LC50 inhibit eggs hatching mL following 72 [11];-1and many cadinenes substances from bo-1 -1 tanical origins 25.411.four mL ) and inhibit eggs hatching (IC50 differences with other[12]. Identificacapable of controlling N. aberrans lies partially on 31.236.71 mL ) tion of sub.
