Product Name :
Dihomo-γ-linolenic acid
Description:
Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system.
CAS:
1783-84-2
Molecular Weight:
306.48
Formula:
C20H34O2
Chemical Name:
(8Z,11Z,14Z)-icosa-8,11,14-trienoic acid
Smiles :
CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(O)=O
InChiKey:
HOBAELRKJCKHQD-QNEBEIHSSA-N
InChi :
InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.1-(4-Chlorophenyl)piperazine Drug Intermediate
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system.|Product information|CAS Number: 1783-84-2|Molecular Weight: 306.48|Formula: C20H34O2|Chemical Name: (8Z,11Z,14Z)-icosa-8,11,14-trienoic acid|Smiles: CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(O)=O|InChiKey: HOBAELRKJCKHQD-QNEBEIHSSA-N|InChi: InChI=1S/C20H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Hydroxyurea Autophagy |Shelf Life: ≥12 months if stored properly.PMID:32762793 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Dihomo-γ-linolenic acid attenuates pro-inflammatory gene expression in human and mouse macrophages. Dihomo-γ-linolenic acid (50 μM; 24 hours) attenuates IFN-γ induced phosphorylation of STAT1 on serine 727. Dihomo-γ-linolenic acid attenuates IL-1β and TNF-α induced MCP-1 and ICAM-1 expression in human macrophages. Dihomo-γ-linolenic acid attenuates chemokine-driven monocytic migration and macrophage foam cell formation. Dihomo-γ-linolenic acid attenuates the expression of SR-A and CD36 in human macrophages. Dihomo-γ-linolenic acid modulates mitochondrial respiration. Dihomo-γ-linolenic acid modulates the properties of endothelial cells and VSMC.|In Vivo:|Dihomo-γ-linolenic acid (8 mg/mouse; i.g; twice a week; for 35 days) inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA.|Products are for research use only. Not for human use.|
