Product Name :
Propargyl-PEG5-amine
Description:
Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
CAS:
1589522-46-2
Molecular Weight:
275.34
Formula:
C13H25NO5
Chemical Name:
3,6,9,12,15-pentaoxaoctadec-17-yn-1-amine
Smiles :
C#CCOCCOCCOCCOCCOCCN
InChiKey:
BLBTXXAWMPTQOK-UHFFFAOYSA-N
InChi :
InChI=1S/C13H25NO5/c1-2-4-15-6-8-17-10-12-19-13-11-18-9-7-16-5-3-14/h1H,3-14H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Vudalimab MedChemExpress
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Propargyl-PEG5-amine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.|Product information|CAS Number: 1589522-46-2|Molecular Weight: 275.Fmoc-Ser(tBu)-OH medchemexpress 34|Formula: C13H25NO5|Chemical Name: 3,6,9,12,15-pentaoxaoctadec-17-yn-1-amine|Smiles: C#CCOCCOCCOCCOCCOCCN|InChiKey: BLBTXXAWMPTQOK-UHFFFAOYSA-N|InChi: InChI=1S/C13H25NO5/c1-2-4-15-6-8-17-10-12-19-13-11-18-9-7-16-5-3-14/h1H,3-14H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32172640 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|References:|Robert Zamboni, et al. Raf-degrading conjugate compounds. WO2018200981A1.Products are for research use only. Not for human use.|
