Biotinylated Human BCMA/TNFRSF17 Protein, His-Avi Tag

Description :
FAQ COA 已发表文献 Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNFreceptor superfamily.It isa type III membrane protein containing one extracellular cysteine rich domain.This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. TNFRSF17 can binds to TNFSF13B/BLyS/BAFF and TNFSF13/APRIL,and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. 产品性质 Synonyms TNFRSF17; BCM; CD269 Uniprot No. Q02223-1 Source Recombinant Biotinylated Human BCMA/TNFRSF17 Protein is expressed from HEK293 Cellswith His tag and Avi tag at the C-terminal. It contains Met1-Ala54. Molecular Weight The protein has a predicted MW of 8.9 kDa. Due to glycosylation, the protein migrates to 12 kDa and 15-17 kDa based on Tris-Bis PAGE result. Physical Appearance Sterile Filtered White lyophilized (freeze-dried) powder. Purity > 95% as determined by SDS-PAGE and HPLC Endotoxin 1.0EU per 1g of the protein by the LAL method. Formulation Lyophilized from 0.22m filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization. Reconstitution Centrifuge tubes before opening. Reconstituting to a concentration more than 100g/mLis recommended. Dissolve the lyophilized protein in distilled water.