Recombinant FITC-Labeled Human EGFR/HER1 Protein, His-Avi Tag

Description :
FAQ COA 已发表文献 The EGFR subfamily of receptor tyrosine kinases comprises four members: EGFR ( HER-1), ErbB2, ErbB3, and ErbB4. EGFR binds a subset of the EGF family ligands, including EGF, amphiregulin, TGF-alpha, betacellulin, epiregulin, HB-EGF, and epigen . Ligand binding induces EGFR homodimerization as well as heterodimerization with ErbB2, resulting in kinase activation, heterodimerization tyrosine phosphorylation and cell signaling. 产品性质 Synonyms ErbB; EC 2.7.10; EC 2.7.10.1; EGFR; mENA; LEGFR; ERBB; ERBB1; HER1; PIG61; NISBD2 Uniprot No. P00533-1 Source Recombinant FITC-Labeled Human EGFR/HER1 Protein is expressed from HEK293 Cells with His tag and Avi tag at the C-terminal. It contains Leu25-Ser645. Molecular Weight The protein has a predicted MW of 71.5 kDa. Due to glycosylation, the protein migrates to 90-115 kDa based on Tris-Bis PAGE result. Purity > 95% as determined by SDS-PAGE. Endotoxin 1.0EU per 1g of the protein by the LAL method. Formulation Supplied as 0.22m filtered solution in PBS (pH 7.4).