Recombinant Mouse IL-12 Protein

Description :
FAQ COA 已发表文献 Interleukin-12 (IL-12), also known as NKSF, TCMF, CLMF and TSF, is a heterodimeric cytokine composed of p35 and p40 subunits. It is produced by monocytes, macrophages, B cells and dendritic cells in response to bacterial lipopolysaccharides and intracellular pathogens. IL-12 signals throughtheIL-12 receptor complex, which is comprised of IL-12 R1 and IL-12 R2. IL-12 induces the proliferation and activation of hematopoietic stem cells, natural killer cells and T- cells. It is indispensible during the development of Th1 cells, leading to the production of IFN-gamma and IL-2. Product Properties Synonyms IL-12a ; IL-12b ; IL-12p35 ; IL-12p40 ; IL12p40 ; IL12a ; p35 ; p40;IL12 Accession p35:P43431 p40: P43432 Source CHO-derived MouseIL-12protein, IL-12 p35 (Arg23-Ser215) & IL-12 p40 (Met23-Ser335). Molecular Weight 27~29 kDa (p35), 45~50 kDa (p40), on SDS-PAGE under reducing conditions. Tag None Purity > 95% by SDS-PAGE. Biological Activity ED50 Endotoxin 0.2EUper 1g of the protein by the LAL method. Formulation Lyophilized after extensive dialysis against PBS. Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O or PBS up to 100 g/ml.For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added.