Recombinant Human CD117 Protein, His Tag

Description :
FAQ COA 已发表文献 c-Kit /CD117, is a receptor tyrosine kinase. Binding of SCF R to SCF, promotes the survival, differentiation, and mobilization of progenitor cells in multiple lineages. Mutations or deletions of SCF R cause a wide variety of malignancies as well as pigmentation disorders and sterility. Within the ECD, human SCF R shares 73% and 76% aa sequence identity with mouse and rat SCF R, respectively. 产品性质 Synonyms SCFR; PBT; CD117; ckit; c-kit; EC 2.7.10; EC 2.7.10.1; KIT Uniprot No. P10721.2 Source Recombinant Human CD117Protein is expressed from HEK293Cellswith His tag at the C-terminal. It contains Gln26-Thr516. Molecular Weight Approximately 56.3 kDa. Due to glycosylation, the protein migrates to 70-100 kDa based on Tris-Bis PAGE result. Purity > 95% as determined by SDS-PAGEand HPLC. Endotoxin 1.0EU per 1g of the protein by the LAL method. Formulation Lyophilized from 0.22m filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization. Reconstitution Centrifuge tubes before opening. Reconstituting to a concentration more than 100 g/mL is recommended. Dissolve the lyophilized protein in distilled water.