Recombinant Human LILRA6/CD85b/ILT8 (His-Avi Tag)

Description :
FAQ COA 已发表文献 LILRA6, also known as ILT8 and CD85b, is a transmembrane molecule that belongs to the LILR family of immune regulatory proteins. Among family members, LILRA6 is most closely related to LILRB3/CD85a/ILT5; these proteins share 94% amino acid (aa) sequence identity in their extracellular domains (ECD). Mature human LILRA6 consists of a 424 aa ECD with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 13 aa cytoplasmic domain. It contains a positively charged arginine residue in the transmembrane segment which may mediate association with the signaling protein Fc epsilon RI gamma. Alternative splicing generates a short isoform that is truncated near the middle of the ECD. LILRA6 is highly polymorphic, and its gene is found in variably copy numbers. LILRA6 is primarily expressed on monocytes. 产品性质 别名 7M1; CD85b; ILT8; LILRA6; Pira3 Uniprot No. Q6PI73.1 Recombinant Human LILRA6/CD85b/ILT8Protein is expressed from HEK293Cells with His tag and Avi tag at the C-terminal. It contains Gly24-Asn447. 分子量 Approximately 49.2 kDa. Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result. > 95% as determined by SDS-PAGEand HPLC. 内毒素 1.0EU per 1g of the protein by the LAL method. Lyophilized from 0.22m filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization. 复溶 Centrifuge tubes before opening. Reconstituting to a concentration more than 100 g/mL is recommended (usually we use 1mg/mLsolution for lyophilization). Dissolve the lyophilized protein in distilled water.