Recombinant Human LILRA3/CD85e (His-Avi Tag)

Description :
FAQ COA 已发表文献 Human LILRA3, also known as Leukocyte Ig-like receptor 4 (LIR-4), CD85 antigen-like family member E, Immunogobulin-like transcript 6 (ILT-6) and monocyte inhibitory receptor HM43/HM31, is a 70 kD Ig superfamily member that belongs to the leukocyte receptor complex/cluster. Mature LILRA3 is 416 amino acids (aa) in length and contains four C2-type Ig-like domains. Unlike other LILR family members, LILRA3 is actively secreted. Alternative splicing generates additional isoforms with one containing an extra 18 aa in the signal peptide and/or a 64 amino acid deletion in the C-terminal half of the second Ig-like domain. Human LILRA3 shares ~86% aa identity with Chimpanzee LILRA3. Human LILRA3 acts as a soluble receptor for class I MHC antigens. It binds both classical and nonclassical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. 产品性质 别名 CD85e; HM31; HM43; ILT6; ILT-6; LILRA3; LIR4; LIR-4HM43e3 Uniprot No. Q8N6C8 Recombinant Human LILRA3/CD85eProtein is expressed from HEK293Cells with His tag and Avi tag at the C-terminal. It contains Gly24-Glu439. 分子量 Approximately 47.9 kDa. Due to glycosylation, the protein migrates to 68-72 kDa based on Tris-Bis PAGE result. > 95% as determined by SDS-PAGE. 内毒素 1.0EU per 1g of the protein by the LAL method. Lyophilized from 0.22m filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization. 复溶 Centrifuge tubes before opening. Reconstituting to a concentration more than 100 g/mL is recommended (usually we use 1mg/mLsolution for lyophilization). Dissolve the lyophilized protein in distilled water.