Recombinant Human LILRA1/CD85i /LIR-6 (His-Avi Tag)

Description :
FAQ COA 已发表文献 LILRA1, also known as CD85i and LIR-6, is an approximately 70 kDa variably glycosylated transmembrane protein that regulates immune cell activation. Mature human LILRA1 consists of a 445 amino acid (aa) extracellular domain (ECD) with 4 Ig-like domains, a 21 aa transmembrane segment, and a 7 aa cytoplasmic tail. The transmembrane segment contains a positively charged arginine which may mediate association with signaling molecules. Alternative splicing generates an isoform that lacks the third and fourth Ig-like domains. LILRA1 is expressed on monocytes and binds to the free heavy chain of the MHC class I molecule HLA-B27. It is activated in response to the BCG mycobacterial strain. 产品性质 别名 CD85i; LILRA1; LIR6; LIR-6; LIR6MGC126563 Uniprot No. O75019.1 Recombinant Human LILRA1/CD85i/LIR-6Protein is expressed from HEK293Cells with His tag and Avi tag at the C-terminal. It contains Pro17-Asn461. 分子量 Approximately 51.4 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Tris-Bis PAGE result. > 95% as determined by SDS-PAGEand HPLC. 内毒素 1.0EU per 1g of the protein by the LAL method. Lyophilized from 0.22m filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization. 复溶 Centrifuge tubes before opening. Reconstituting to a concentration more than 100 g/mL is recommended (usually we use 1mg/mLsolution for lyophilization). Dissolve the lyophilized protein in distilled water.