Recombinant Human FGFR4(hFc Tag)

Description :
FAQ COA 已发表文献 Fibroblast growth factor receptor 4 (FGF R4), also known as CD334, is a 110 kDa glycosylated transmembrane receptor tyrosine kinase. Within the ECD, human FGF R4 shares 90% and 88% aa sequence identity with mouse and rat FGF R4, respectively. A 65 kDa Nterminally truncated isoform lacks the signal peptide and first two Iglike domains. This isoform is produced in human pituitary adenomas and is constitutively phosphorylated and oncogenic. FGF R4 is widely expressed during embryonic development and in adult liver, kidney, and lung. It binds FGF acidic, FGF basic, FGF8, -15, and -19. FGFR4 supports glucose tolerance and insulin sensitivity and protects against hyperlipidemia. It is downregulated in the liver during fasting and is upregulated by insulin. It can exert either proliferative or apoptotic effects on hepatocytes. 产品性质 别名Synonyms CD334, FGF R4, FGFR4, FGFR-4, MGC20292, JTK2, TKF Uniprot No. P22455 Source Recombinant Human FGFR4Protein is expressed from HEK293Cellswith hFctag at the C-terminal. It contains Leu22-Asp369. 分子量(Molecular Weight) Approximately 65.3kDa.Due to glycosylation, the protein migrates to80-95kDa based on Tris-Bis PAGE result. 外观(Physical Appearance Sterile Filtered White lyophilized (freeze-dried) powder. Purity > 95% as determined by SDS-PAGEand HPLC Activity Testing in progress 内毒素Endotoxin 1.0EU per 1g of the protein by the LAL method. Formulation Lyophilized from 0.22m filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization. 复溶Reconstitution Centrifuge tubes before opening. Reconstituting to a concentration more than 100 g/mL`is recommended (usually we use 1mg/mLsolution for lyophilization). Dissolve the lyophilized protein in distilled water.