Human IFN-λ1/IL-29

Description :
FAQ COA 已发表文献 IFN 1, 2, and3(also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and the interferons.All three IFN-lambdas use a distinct receptor system composed of an IFN-R1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14).Signaling through this receptor system induces antiviral defenses similar to, but distinct from, that of type I interferons.Recombinant Human IFN-1 is a 19.8 kDa protein containing 178 amino acid residues. Product Properties Synonyms Cytokine Zcyto21 Accession Q8IU54 GeneID 282618 Source E.coli-derived Human IFN-1protein,Gly20-Thr200. Molecular Weight Approximately 19.8 kDa. AA Sequence GPVPTSKPTT TGKGCHIGRF KSLSPQELAS FKKARDALEE SLKLKNWSCS SPVFPGNWDL RLLQVRERPV ALEAELALTL KVLEAAAGPA LEDVLDQPLH TLHHILSQLQ ACIQPQPTAG PRPRGRLHHW LHRLQEAPKK ESAGCLEASV TFNLFRLLTR DLKYVADGNL CLRTSTHPES T Tag None Physical Appearance Sterile Filtered White lyophilized (freeze-dried) powder. Purity > 97% by SDS-PAGE and HPLC analyses. Biological Activity Fully biologically active when compared to standard. The ED50as determined by an anti-viral assay using human HepG2 cells infected with encephalomyocarditis is less than 5 ng/mL, corresponding to a specific activity of > 2.0 105IU/mg. Endotoxin Formulation Lyophilized from a 0.2 m filtered concentrated solution in PBS, pH 7.4. Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at -20 C. Further dilutions should be made in appropriate buffered solutions.