Recombinant Human PTHrP

Description :
FAQ COA 已发表文献 PTHrP, also named parathyroid hormone-related protein, is belonging to the parathyroid hormone family. PTHrP is expressed in cancer cells (breast cancer, certain types of lung cancer including squamous cell lung carcinoma). The receptor for PTHrP is PTHR1. PTHrP plays a central role in regulating the hypercalcemia. Recombinant human PTHrP is a 9.9 kDa linear polypeptide of 86 amino acid residues and it shares 86 % a.a. identity with mouse PTHLH. Product Properties Synonyms Parathormone, Parathyrin Accession P12272 GeneID 5744 Source E.coli-derived human PTHrP protein, Ala37-Pro122. Molecular Weight Approximately 9.9 kDa. AA Sequence AVSEHQLLHD KGKSIQDLRR RFFLHHLIAE IHTAEIRATS EVSPNSKPSP NTKNHPVRFG SDDEGRYLTQ ETNKVETYKE QPLKTP Tag None Physical Appearance Sterile Filtered White lyophilized (freeze-dried) powder. Purity >98% by SDS-PAGE and HPLC analyses. Biological Activity Testing in progress. Endotoxin Formulation Lyophilized from a 0.2 m filtered concentrated solution in 10 mM PB, pH 6.0, 300 mM NaCl. Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at -20. Further dilutions should be made in appropriate buffered solutions.