Recombinant HBV Surface Antigen (adr)

Description :
FAQ COA 已发表文献 The large envelope protein exists in two topological conformations, one which is termed ‘external’ or Le-HBsAg and the other ‘internal’ or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein. Product Properties Synonyms HBsAgadr; Hepatitis B virus surface antigen Source CHO derived HBsAgadr Molecular Weight Approximately 23.0-27.0 kDa on a reducing SDS-PAGE. Tag None Physical Appearance Sterile liquid. Concentration 0.608 mg/ml Purity > 95 % by HPLC analyses. Biological Activity The biological activity is determined by ELISA with anti-HBsAg antibodies. Endotoxin Formulation Sterile Filtered solution containing 20 mM PB, 154 mM NaCl.