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Product Name :
Recombinant Human/Mouse/Rat BMP-2 Protein

Description :
FAQ COA 已发表文献 骨形态发生蛋白 2 (BMP-2)是 BMP亚群的成员其中BMP2-7属于 TGF-超家族它在胚胎背腹模式器官发生肢芽形成以及骨形成和再生中起主导作用 成熟的人BMP-2 与小鼠和大鼠 BMP-2具有100% 的aa序列同一性 它与人类 BMP-4 的序列同一性为 85%与其他 BMP 的序列同一性不到 51%正常的骨形成是一个经过仔细调节的长期过程涉及成骨细胞在增殖和最终分化时连续表达生长调节因子由于成骨细胞基因表达的这种有序序列表明了级联效应BMP-2 能够启动和维持这种效应 BMP-2 还促进结肠上皮的维持和修复抑制神经元多巴胺的合成和释放诱导髓母细胞瘤细胞凋亡并且是心肌收缩力所必需的 产品性质 别名 BDA2,BMP2,BMP-2,BMP-2A,SSFSC Uniprot No. P12643 GeneID 650 E.coli-derived human BMP-2, Gln283-Arg396, with an N-terminal Met. 分子量 Approximately 26.0 kDa. 标签 None 外观 Sterile Filtered White lyophilized (freeze-dried) powder. >95% by SDS-PAGE and HPLC analyses. 生物 The ED50as determined by inducing alkaline phosphatase production of murine ATDC5 cells is less than 200 ng/mL, corresponding to a specific activity of > 5.0 103IU/mg.Fully biologically active when compared to standard. 内毒素 1.0EUper 1g of the protein by the LAL method. Lyophilized from a 0.2 m filtered concentrated solution in10 mM sodium citrate,pH 3.5. 建议在打开之前进行短暂离心以将内容物带到底部 在无菌蒸馏水中复溶至 0.1-1.0 mg/mL 的浓度储备溶液等分分装并储存在 -20C 在适当的缓冲溶液中进行进一步稀释 不要在PBS 或细胞培养基中复溶

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MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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