Lished: 13 December 2013 Reference 1. Demer LL, Tintut Y: Vascular calcification: pathobiology of a multifaceted illness. Circulation 2008, 117(22):2938948. 2. Blacher J, Guerin AP, Pannier B, Marchais SJ, London GM: Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal IP Activator Storage & Stability disease. Hypertension 2001, 38:93842. 3. Boyle WJ, Simonet WS, Lacey DL: Osteoclast differentiation and activation. Nature 2003, 423:33742. 4. Pai A, Leaf EM, El-Abbadi M, Giachelli CM: Elastin degradation and vascular smooth muscle cell phenotype adjust precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease. Am J Pathol 2011, 178(2):76473. 5. Shanahan CM, Crouthamel MH, Kapustin A, Giachelli CM: Arterial calcification in chronic kidney disease: essential roles for calcium and phosphate. Circ Res 2011, 109(6):69711. six. Mozar A, Haren N, Chasseraud M, Louvet L, Mazi e C, Wattel A, Mentaverri R, Morli e P, Kamel S, Brazier M, et al: Higher extracellular inorganic phosphate concentration inhibits RANK ANKL signaling in osteoclastlike cells. J Cell Physiol 2008, 215(1):474. 7. Tonelli M, Pannu N, Manns B: Oral phosphate binders in patients with kidney failure. N Engl J Med 2010, 362(14):1312324. 8. Sprague SM, Abboud H, Qiu P, Dauphin M, Zhang P, Finn W: Lanthanum carbonate reduces phosphorus burden in sufferers with CKD stages three and four: a randomized trial. Clin J Am Soc Nephrol 2009, four(1):17885.9.ten. 11.12.13.14.15.16. 17.18.19.20.21. 22.23.24.25.26.Helas S, Goettsch C, Schoppet M, Zeitz U, Hempel U, Morawietz H, Kostenuik PJ, Erben RG, Hofbauer LC: Inhibition of receptor activator of NF-kappaB ligand by denosumab attenuates vascular calcium deposition in mice. Am J Pathol 2009, 175(two):47378. Hofbauer LC, Schoppet M: Osteoprotegerin: a hyperlink among osteoporosis and arterial calcification Lancet 2001, 358(9278):25759. Park JK, Rosen A, Saffitz JE, Asimaki A, Litovsky SH, Mackey-Bojack SM, Halushka MK: Expression of cathepsin K and tartrate-resistant acid phosphatase just isn’t confined to osteoclasts but is a common feature of multinucleated giant cells: systematic evaluation. Rheumatology 2013, 52(eight):1529533. Neven E, Persy V, Dauwe S, Schutter TD, Broe MED, D’Haese Computer: Chondrocyte as an alternative to osteoblast conversion of vascular cells underlies medial calcification in uremic rats. Arterioscler Thromb Vasc Biol 2010, 30(9):1741750. Price P, Roublick A, Williamson M: Artery calcification in uremic rats is elevated by a low Bradykinin B2 Receptor (B2R) Antagonist supplier protein diet plan and prevented by remedy with ibandronate. Kidney Int 2006, 70:1577583. Speer MY, Li X, Hiremath PG, Giachelli CM: Runx2/Cbfa1, but not loss of myocardin, is essential for smooth muscle cell lineage reprogramming toward osteochondrogenesis. J Cell Biochem 2010, 110(four):93547. Sowa A-K, Kaiser FJ, Eckhold J, Kessler T, Aherrahrou R, Wrobel S, Kaczmarek PM, Doehring L, Schunkert H, Erdmann J, et al: Functional interaction of osteogenic transcription factors Runx2 and Vdr in transcriptional regulation of Opn for the duration of soft tissue calcification. Am J Pathol 2013, 183(1):608. Komori T: Regulation of osteoblast differentiation by transcription components. J Cell Biochem 2006, 99(five):1233239. Moe SM, Chen NX, Seifert MF, Sinders RM, Duan D, Chen X, Liang Y, Radcliff JS, White KE, Gattone VH: A rat model of Chronic Kidney Disease-Mineral Bone Disorder(CKD-MBD) and the impact of dietary protein supply. Kidney Int 2009, 75(two):17684. Panizo S, Cardus A, Encinas M, Parisi E, Valcheva P, L ez-Ongil S.