ing NLRP3 aspase-1 signaling pathway (Figure 9). The outcomes of thi demonstrate that curcumin was an that curcumin was an efficient feed additive to suppress liver injur study demonstrate successful feed additive to suppress liver injury induced by AFB1, supplying a potential guarantee for possible guaranteeandproduction in economic induced by AFB1, delivering a production safety for reduction security and reduction i losses induced by AFB1 contamination inside the poultry breeding market. breeding sector. financial losses induced by AFB1 contamination in the poultry5. ConclusionsFigure 9. The mechanism of dietary curcumin alleviated liver harm induced by AFB1. Figure 9. The mechanism of dietary curcumin alleviated liver harm induced by AFB1.Supplementary Components: The following are available on line at mdpi/article/ ten.3390/foods10123086/s1, Table S1 shows the experiment design and style; Table S2 shows the ingredient composition and nutrient content on the basal eating plan ( , as-fed basis); Table S3 shows the accession GSK-3 medchemexpress quantity, Primer sequence, and solution size of target genes.Foods 2021, 10,14 ofAuthor Contributions: S.J. and X.F. led the experimental CDK11 supplier function. S.J. wrote the very first draft in the manuscript. S.J., H.Y., Y.W., Q.P., and Y.J. performed the feeding ducks for 70 days and determined the key experiments assay. A.S. reviewed the manuscript. X.F. reviewed and edited the manuscript. All authors have read and agreed to the published version from the manuscript. Funding: This operate was supported by the National Natural Science Foundation of China (31772638, 32072768) and the All-natural Science Foundation of Heilongjiang Province (C2016022). Institutional Assessment Board Statement: The experimental protocol was performed in compliance using the Guide for the Care and Use of Agricultural Animals in Agriculture Investigation and Teaching of Northeast Agricultural University (Protocol number: NEAU-[2011]-9). Informed Consent Statement: Not applicable. Information Availability Statement: The information utilized and/or analyzed in this study are readily available from the corresponding author on reasonable request. Conflicts of Interest: The authors declare that they’ve no competing interest.AbbreviationsAFB1 TP ALB GLB A/G ALT AST ALP TBIL T-AOC CAT T-SOD GSH GST H2 O2 MDA GSH-Px/GPx Keap1 Nrf2 NQO1 HO-1 GCLC GCLM TXNIP NLRP3 Caspase-1 CYP1A1 CYP1A4 CYP2A6 CYP3A4 Aflatoxin B1 total protein albumin globulin ALB/GLB alanine aminotransferase aspartate aminotransferase alkaline phosphatase total bilirubin total antioxidant capacity catalase total superoxide dismutase reductive glutathione glutathione S-transferase hydrogen peroxide methane dicarboxylic aldehyde glutathione peroxidase Kelch-like ECH-associated protein nuclear issue erythroid 2-related aspect two NAD(P)H quinone oxidoreductase 1 heme oxygenase 1 glutamate cysteine ligase catalyzes subunits glutamic acid cysteine ligase modified subunit thioredoxin interacting protein NOD-like receptor family members pyrin domain containing protein 3 cysteine-dependent aspartate-directed protease-1 cytochrome P450 1A1 cytochrome P450 1A2 cytochrome P450 2A6 cytochrome P450 3A
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