Domains are labelled as stick to: AT–acetylation domain, KS–ketosynthase, and ACP–acyl carrier protein. TE–thioesterase was a typical domain to NRPS and PKS. These domains have several functions within the synthesis from the final molecule. A and AT domains are involved within the choice and activation in the substrate, C and KS domains are involved within the condensation from the substrate AA for amino acid or S for acyl-CoA or malonyl-CoA with the developing NRP or PK, respectively. ACP and PCP play a part in the transfer with the substrate between the diverse modules. TE releases the final molecule. The red arrows rather encode for immunity or resistance genes to the synthesized antibiotic.Microorganisms 2021, 9,5 ofTable 1. Nonribosomal peptide (NRP) and polyketide (PK) molecules applied presently in human medicine.Synthesis Mode Class Antibiotics Penicillin -Lactams Cephalosporin Carbapenem Monobactam RPS Glycopeptides Polypeptides Streptogramins Lincosamides Lipopeptides Vancomycin Polmacoxib inhibitor Teicoplanin Polymyxin Streptogramin B Pristinamycin Lincomycin Daptomycin Erythromycin Macrolides Josamycin Midecamycin Spiramycin PKS Tetracyclines Carboxylic acid Hybrid NRPS/PKS Rifamycins Fidaxomicin Chlortetracycline Mupirocin Rifampicin Organism Penicillium notatum, Penicillium chrysogenum Cephalosporium acremonium
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