[Pemafibrate clinical trials PubMed: 21367916] Mount PF, Power DA. Nitric oxide in the kidney: functions and regulation of synthesis. Acta Physiol (Oxf). 2006; 187:433?6. [PubMed: 16866775] Najafian B, Alpers CE, Fogo AB. Pathology of human diabetic nephropathy. Contributions to nephrology. 2011; 170:36?7. [PubMed: 21659756] Nakagawa T, Sato W, Glushakova O, Heinig M, Clarke T, Campbell-Thompson M, et al. Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy. J Am Soc Nephrol. 2007; 18:539?0. [PubMed: 17202420] Neugarten J, Ding Q, Friedman A, Lei J, Silbiger S. Sex hormones and renal nitric oxide synthases. Journal of the American Society of Nephrology: JASN. 1997; 8:1240?. [PubMed: 9259350]Author Manuscript Author Manuscript Author Manuscript Author ManuscriptActa Histochem. Author manuscript; available in PMC 2017 March 01.Slyvka et al.PageNeugarten J, Silbiger SR. Effects of sex hormones on mesangial cells. American journal of kidney diseases: the official journal of the National Kidney Foundation. 1995; 26:147?1. [PubMed: 7611246] Pfeilschifter J, Eberhardt W, Beck KF. Regulation of gene expression by nitric oxide. Pflugers Archiv: European journal of physiology. 2001; 442:479?6. [PubMed: 11510878] Pfeilschifter J, Eberhardt W, Beck KF, Huwiler A. Redox signaling in mesangial cells. Nephron Experimental nephrology. 2003; 93:e23?. [PubMed: 12411746] Phillips AO, Steadman R. Diabetic nephropathy: the central role of renal proximal tubular cells in tubulointerstitial injury. Histology and histopathology. 2002; 17:247?2. [PubMed: 11813875] Prabhakar S, Starnes J, Shi S, Lonis B, Tran R. Diabetic nephropathy is associated with oxidative stress and decreased renal nitric oxide production. J Am Soc Nephrol. 2007; 18:2945?2. [PubMed: 17928507] Ptilovanciv EO, Fernandes GS, Teixeira LC, Reis LA, Pessoa EA, Convento MB, et al. Heme oxygenase 1 improves glucoses metabolism and kidney histological alterations in diabetic rats. Diabetology metabolic syndrome. 2013; 5:3. [PubMed: 23321053] Raij L, Baylis C. Glomerular actions of nitric oxide. Kidney International. 1995; 48:20?2. [PubMed: 7564080] Raij L, Shultz PJ. Endothelium-derived relaxing factor, nitric oxide: effects on and production by mesangial cells and the glomerulus. J Am Soc Nephrol. 1993; 3:1435?1. [PubMed: 8387828] Romagnani P, Pupilli C, Lasagni L, Baccari MC, Bellini F, Amorosi A, et al. Inducible nitric oxide synthase expression in vascular and glomerular structures of human chronic allograft nephropathy. J Pathol. 1999; 187:345?0. [PubMed: 10398090] get (R)-K-13675 Rupprecht HD, Akagi Y, Keil A, Hofer G. Nitric oxide inhibits growth of glomerular mesangial cells: role of the transcription factor EGR-1. Kidney Int. 2000; 57:70?2. [PubMed: 10620189] Schena FP, Gesualdo L. Pathogenetic mechanisms of diabetic nephropathy. J Am Soc Nephrol. 2005; 16(Suppl 1):S30?. [PubMed: 15938030] Sego S. Pathophysiology of diabetic nephropathy. Nephrol Nurs J. 2007; 34:631?. [PubMed: 18203571] Shin SJ, Lai FJ, Wen JD, Hsiao PJ, Hsieh MC, Tzeng TF, et al. Neuronal and endothelial nitric oxide synthase expression in outer medulla of streptozotocin-induced diabetic rat kidney. Diabetologia. 2000; 43:649?9. [PubMed: 10855540] Slyvka Y, Inman SR, Malgor R, Jackson EJ, Yee J, Oshogwemoh O, et al. Protective effects of antioxidant fortified diet on renal function and metabolic profile in obese Zucker rat. Endocrine. 2009; 39:89?00. [PubMed: 19051067] Slyvka Y, Wang Z, Yee J, Inman SR, Nowak FV. Antioxi.[PubMed: 21367916] Mount PF, Power DA. Nitric oxide in the kidney: functions and regulation of synthesis. Acta Physiol (Oxf). 2006; 187:433?6. [PubMed: 16866775] Najafian B, Alpers CE, Fogo AB. Pathology of human diabetic nephropathy. Contributions to nephrology. 2011; 170:36?7. [PubMed: 21659756] Nakagawa T, Sato W, Glushakova O, Heinig M, Clarke T, Campbell-Thompson M, et al. Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy. J Am Soc Nephrol. 2007; 18:539?0. [PubMed: 17202420] Neugarten J, Ding Q, Friedman A, Lei J, Silbiger S. Sex hormones and renal nitric oxide synthases. Journal of the American Society of Nephrology: JASN. 1997; 8:1240?. [PubMed: 9259350]Author Manuscript Author Manuscript Author Manuscript Author ManuscriptActa Histochem. Author manuscript; available in PMC 2017 March 01.Slyvka et al.PageNeugarten J, Silbiger SR. Effects of sex hormones on mesangial cells. American journal of kidney diseases: the official journal of the National Kidney Foundation. 1995; 26:147?1. [PubMed: 7611246] Pfeilschifter J, Eberhardt W, Beck KF. Regulation of gene expression by nitric oxide. Pflugers Archiv: European journal of physiology. 2001; 442:479?6. [PubMed: 11510878] Pfeilschifter J, Eberhardt W, Beck KF, Huwiler A. Redox signaling in mesangial cells. Nephron Experimental nephrology. 2003; 93:e23?. [PubMed: 12411746] Phillips AO, Steadman R. Diabetic nephropathy: the central role of renal proximal tubular cells in tubulointerstitial injury. Histology and histopathology. 2002; 17:247?2. [PubMed: 11813875] Prabhakar S, Starnes J, Shi S, Lonis B, Tran R. Diabetic nephropathy is associated with oxidative stress and decreased renal nitric oxide production. J Am Soc Nephrol. 2007; 18:2945?2. [PubMed: 17928507] Ptilovanciv EO, Fernandes GS, Teixeira LC, Reis LA, Pessoa EA, Convento MB, et al. Heme oxygenase 1 improves glucoses metabolism and kidney histological alterations in diabetic rats. Diabetology metabolic syndrome. 2013; 5:3. [PubMed: 23321053] Raij L, Baylis C. Glomerular actions of nitric oxide. Kidney International. 1995; 48:20?2. [PubMed: 7564080] Raij L, Shultz PJ. Endothelium-derived relaxing factor, nitric oxide: effects on and production by mesangial cells and the glomerulus. J Am Soc Nephrol. 1993; 3:1435?1. [PubMed: 8387828] Romagnani P, Pupilli C, Lasagni L, Baccari MC, Bellini F, Amorosi A, et al. Inducible nitric oxide synthase expression in vascular and glomerular structures of human chronic allograft nephropathy. J Pathol. 1999; 187:345?0. [PubMed: 10398090] Rupprecht HD, Akagi Y, Keil A, Hofer G. Nitric oxide inhibits growth of glomerular mesangial cells: role of the transcription factor EGR-1. Kidney Int. 2000; 57:70?2. [PubMed: 10620189] Schena FP, Gesualdo L. Pathogenetic mechanisms of diabetic nephropathy. J Am Soc Nephrol. 2005; 16(Suppl 1):S30?. [PubMed: 15938030] Sego S. Pathophysiology of diabetic nephropathy. Nephrol Nurs J. 2007; 34:631?. [PubMed: 18203571] Shin SJ, Lai FJ, Wen JD, Hsiao PJ, Hsieh MC, Tzeng TF, et al. Neuronal and endothelial nitric oxide synthase expression in outer medulla of streptozotocin-induced diabetic rat kidney. Diabetologia. 2000; 43:649?9. [PubMed: 10855540] Slyvka Y, Inman SR, Malgor R, Jackson EJ, Yee J, Oshogwemoh O, et al. Protective effects of antioxidant fortified diet on renal function and metabolic profile in obese Zucker rat. Endocrine. 2009; 39:89?00. [PubMed: 19051067] Slyvka Y, Wang Z, Yee J, Inman SR, Nowak FV. Antioxi.
