Jagged1 and Delta1 signalling via Notch1 and Notch2. Nat Cell Biol 2: 515520. 24. Morimoto M, Takahashi Y, Endo M, Saga Y The Mesp2 transcription aspect establishes segmental borders by suppressing Notch activity. Nature 435: HIV-RT inhibitor 1 manufacturer 354359. 25. Panin V, Papayannopoulos V, Wilson R, Irvine KD Fringe modulates Notch-ligand interactions. Nature 387: 908912. 26. Okajima T, Reddy B, Matsuda T, Irvine KD Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling. BMC Biol 6: 1. 27. Okajima T, Matsuura A, Matsuda T Biological Functions of Glycosyltransferase Genes Involved in O-fucose Glycan Synthesis. J Biochem 144: 16. 28. Okajima T, Xu A, Lei L, Irvine KD Chaperone activity of protein Ofucosyltransferase 1 promotes notch receptor folding. Science 307: 15991603. 29. Sasamura T, Ishikawa HO, Sasaki N, Higashi S, Kanai M, et al. The Ofucosyltransferase O-fut1 is an extracellular component that is certainly important for the constitutive endocytic trafficking of Notch in Drosophila. Development 134: 13471356. 30. 18325633 Stahl M, Uemura K, Ge C, Shi S, Tashima Y, et al. Roles of Pofut1 and O-fucose in mammalian Notch signaling. J Biol Chem 283: 1363813651. 31. Yao D, Huang Y, Huang X, Wang W, Yan Q, et al. Protein Ofucosyltransferase 1 regulates lymphoid and myeloid homeostasis 1. Shi S, Ge C, Luo Y, Hou X, Haltiwanger RS, et al. The Threonine That Carries Fucose, but Not Fucose, Is Expected for Cripto to Facilitate Nodal Signaling. J Biol Chem 282: 2013320141. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. by means of modulation of Notch receptor ligand interactions. Blood 117: 5652 5662. Okamura Y, Saga Y Pofut1 is needed for the correct localization of your Notch receptor throughout mouse improvement. Mech Dev 125: 663673. Panin V, Shao L, Lei L, Moloney D, Irvine KD, et al. Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe. J Biol Chem 277: 2994529952. Geffers I, Serth K, Chapman G, Jaekel R, Schuster-Gossler K, et al. Divergent functions and distinct localization from the Notch ligands DLL1 and DLL3 in vivo. J Cell Biol 178: 465476. Schambach A, Bohne J, Chandra S, Will E, Margison GP, et al. Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6methylguanine-DNA methyltransferase in hematopoietic cells. Mol Ther 13: 391400. Schneider CA, Rasband WS, Eliceiri KW NIH Image to ImageJ: 25 years of image KDM5A-IN-1 biological activity evaluation. Nat Solutions 9: 671675. Al-Shareffi E, Chaubard J-L, Leonhard-Melief C, Wang S-K, Wong C-H, et al. 6-alkynyl fucose is actually a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin type-1 repeats by protein Ofucosyltransferases 1 and 2. Glycobiology 23: 188198. Rana NA, Nita-Lazar A, Takeuchi H, Kakuda S, Luther KB, et al. Oglucose trisaccharide is present at high but variable stoichiometry at several web sites on mouse Notch1. J Biol Chem 286: 3162331637. Harris RJ, Spellman MW O-linked fucose and also other post-translational modifications distinctive to EGF modules. Glycobiology three: 219224. Morth JP, Pedersen BP, Buch-Pedersen MJ, Andersen JP, Vilsen B, et al. A structural overview with the plasma membrane Na+,K+2ATPase and H+2ATPase ion pumps. Nat Rev Mol Cell Biol 12: 6070. Yan Y-T, Liu J-J, Luo Y, E C, Haltiwanger RS, et al. Dual roles of Cripto as a ligand and coreceptor inside the nodal signaling pathway. Mol Cell Biol 22: 44394449. Shi S, Ge C, Luo Y, Hou X, Haltiwanger RS, et al. The Threonine That Carries Fucose, but Not Fucose, Is Expected.Jagged1 and Delta1 signalling via Notch1 and Notch2. Nat Cell Biol two: 515520. 24. Morimoto M, Takahashi Y, Endo M, Saga Y The Mesp2 transcription issue establishes segmental borders by suppressing Notch activity. Nature 435: 354359. 25. Panin V, Papayannopoulos V, Wilson R, Irvine KD Fringe modulates Notch-ligand interactions. Nature 387: 908912. 26. Okajima T, Reddy B, Matsuda T, Irvine KD Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling. BMC Biol 6: 1. 27. Okajima T, Matsuura A, Matsuda T Biological Functions of Glycosyltransferase Genes Involved in O-fucose Glycan Synthesis. J Biochem 144: 16. 28. Okajima T, Xu A, Lei L, Irvine KD Chaperone activity of protein Ofucosyltransferase 1 promotes notch receptor folding. Science 307: 15991603. 29. Sasamura T, Ishikawa HO, Sasaki N, Higashi S, Kanai M, et al. The Ofucosyltransferase O-fut1 is definitely an extracellular component that is vital for the constitutive endocytic trafficking of Notch in Drosophila. Development 134: 13471356. 30. 18325633 Stahl M, Uemura K, Ge C, Shi S, Tashima Y, et al. Roles of Pofut1 and O-fucose in mammalian Notch signaling. J Biol Chem 283: 1363813651. 31. Yao D, Huang Y, Huang X, Wang W, Yan Q, et al. Protein Ofucosyltransferase 1 regulates lymphoid and myeloid homeostasis 1. Shi S, Ge C, Luo Y, Hou X, Haltiwanger RS, et al. The Threonine That Carries Fucose, but Not Fucose, Is Expected for Cripto to Facilitate Nodal Signaling. J Biol Chem 282: 2013320141. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. by means of modulation of Notch receptor ligand interactions. Blood 117: 5652 5662. Okamura Y, Saga Y Pofut1 is required for the proper localization from the Notch receptor throughout mouse improvement. Mech Dev 125: 663673. Panin V, Shao L, Lei L, Moloney D, Irvine KD, et al. Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe. J Biol Chem 277: 2994529952. Geffers I, Serth K, Chapman G, Jaekel R, Schuster-Gossler K, et al. Divergent functions and distinct localization from the Notch ligands DLL1 and DLL3 in vivo. J Cell Biol 178: 465476. Schambach A, Bohne J, Chandra S, Will E, Margison GP, et al. Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6methylguanine-DNA methyltransferase in hematopoietic cells. Mol Ther 13: 391400. Schneider CA, Rasband WS, Eliceiri KW NIH Image to ImageJ: 25 years of image evaluation. Nat Strategies 9: 671675. Al-Shareffi E, Chaubard J-L, Leonhard-Melief C, Wang S-K, Wong C-H, et al. 6-alkynyl fucose is often a bioorthogonal analog for O-fucosylation of epidermal development factor-like repeats and thrombospondin type-1 repeats by protein Ofucosyltransferases 1 and 2. Glycobiology 23: 188198. Rana NA, Nita-Lazar A, Takeuchi H, Kakuda S, Luther KB, et al. Oglucose trisaccharide is present at higher but variable stoichiometry at multiple web pages on mouse Notch1. J Biol Chem 286: 3162331637. Harris RJ, Spellman MW O-linked fucose and also other post-translational modifications unique to EGF modules. Glycobiology 3: 219224. Morth JP, Pedersen BP, Buch-Pedersen MJ, Andersen JP, Vilsen B, et al. A structural overview on the plasma membrane Na+,K+2ATPase and H+2ATPase ion pumps. Nat Rev Mol Cell Biol 12: 6070. Yan Y-T, Liu J-J, Luo Y, E C, Haltiwanger RS, et al. Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway. Mol Cell Biol 22: 44394449. Shi S, Ge C, Luo Y, Hou X, Haltiwanger RS, et al. The Threonine That Carries Fucose, but Not Fucose, Is Expected.